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KMID : 1134120080110040201
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Journal of Breast Cancer
2008 Volume.11 No. 4 p.201 ~ p.205
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Apocrine Carcinoma of the Breast: Clinicopathologic Analysis of 19 Cases
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Sung Min-Ki
Noh Woo-Chul
Kim Min-Suk
Kim Hyun-Ah
Paik Nam-Sun
Moon Nan-Mo
Kim Yang-Hee
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Abstract
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Purpose: Apocrine carcinoma of the breast, a specific histologic type of human breast cancer, is a rare malignant tumor. Because of the rarity of apocrine carcinoma and lack of a standardized definition, the clinicopathologic features have not been definitively determined. In this study, we present a single institution analysis of the clinicopathologic features of 19 cases of apocrine carcinoma and contrast them with those seen in infiltrating ductal carcinoma, not otherwise specified (NOS).
Methods: We respectively reviewed the records of 19 patients with apocrine carcinoma who underwent surgery at Korea Cancer Center Hospital between October 1997 and April 2007.
Results: The mean patient age was 52.8 years. Eight patients (42.1%) were under 50 years of age. In all patients, the initial symptom was a breast mass. Twelve (63.2%) of 19 tumors were located in the right breast and the other 7 cases (36.8%) were located in the left breast. The average tumor size was 2.19 cm (range 0.7-7 cm). Two patients had axillary lymph node metastasis. Estrogen receptor (ER) was positive in 3 cases (16.7%). The HER-2 overexpression rate was 35.3%. There was no locoreginal recurrence, distant metastasis, or death during the median follow-up period of 35.4 months (range 4-114 months).
Conclusion: Compared with the alleged characteristics seen in Korean breast cancer patients, apocrine carcinoma was characterized by an older age at the time of diagnosis and a higher incidence of hormone receptor negatively. The HER- 2 overexpression rate was similar to the rate for other tumors. Although there was a relatively low incidence ER positivity, there was no recurrence or death. Therefore, apocrine carcinoma appears to be clinically distinct from infiltrating ductal carcinoma, NOS.
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KEYWORD
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Breast, Carcinoma, Apocrine
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